FORMATION OF GRANULATION-TISSUE IN SUBCUTANEOUSLY IMPLANTED SPONGES IN RATS - COMPARISON BETWEEN GRANULATION-TISSUE DEVELOPED IN VISCOSE CELLULOSE SPONGES (VISELLA) AND IN POLYVINYL-ALCOHOL SPONGES (IVALON)

  • 1 January 1979
    • journal article
    • research article
    • Vol. 87  (5) , 367-374
Abstract
A comparison was made between the granulation tissue formation in 2 different synthetic sponge types, Visella and Ivalon, of different sizes. The granulation tissue formed in the 2 sponge types did not differ qualitatively, and had the character of wound tissue and inflammatory tissue in man. The rate of tissue formation in the Visella sponges was faster and the tissue was more homogenous than in the Ivalon sponges. Visella implants [14 days old] of either size contained more granulation tissue than Ivalon sponges, probably owing to the smaller pore size of the former material. This may also account for the more frequent occurrence of giant cells in the Visella implants. In contrast to the Visella sponges, the trabeculae of the Ivalon polymer showed calcification and positive staining properties with histological staining procedures and deformation was frequent among the Ivalon implants. Thin sponges of either type closed in about 21 days, thick ones after about 42 days of implantation. Calculated per 2 cm3 of implant, thin sponges produced more tissue after 14 days of implantation than thick ones. The Visella sponge type is best suited for this experimental model of inflammation.