Effects of Na+‐Ca2+ Exchange Expression on Excitation‐Contraction Coupling in Genetically Modified Mice
- 1 June 2005
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1047 (1) , 122-126
- https://doi.org/10.1196/annals.1341.011
Abstract
We have created genetically altered mice to investigate how expression of the Na(+)-Ca(2+) exchange protein alters excitation-contraction (E-C) coupling. Whereas low levels of exchanger overexpression have minimal effects on E-C coupling properties, high levels of overexpression in homozygous animals results in susceptibility to hypertrophy and heart failure, along with a significant reduction in E-C coupling gain. While global knockout of the exchanger in mice is embryonic-lethal, conditional knockout mice live to adulthood. Cardiac function is surprisingly normal in seven-week-old mice, but E-C coupling gain is apparently increased. Thus, genetic modification of exchanger expression has a major influence on E-C coupling.Keywords
This publication has 20 references indexed in Scilit:
- Functional Adult Myocardium in the Absence of Na + -Ca 2+ ExchangeCirculation Research, 2004
- Cardiac excitation–contraction coupling in the absence of Na+–Ca2+ exchangeCell Calcium, 2003
- The Na+/Ca2+ Exchange MoleculeAnnals of the New York Academy of Sciences, 2002
- Knockout Mice for Pharmacological ScreeningCirculation Research, 2002
- Cardiac excitation–contraction couplingNature, 2002
- Arrhythmogenesis and Contractile Dysfunction in Heart FailureCirculation Research, 2001
- Na+−Ca2+ exchange and sarcoplasmic reticular Ca2+ regulation in ventricular myocytes from transgenic mice overexpressing the Na+−Ca2+ exchangerThe Journal of Physiology, 1998
- L-type Calcium Channel Abundance and Function with Cardiac Hypertrophy and Failure: A ReviewJournal of Molecular and Cellular Cardiology, 1998
- Calcium Signaling in Transgenic Mice Overexpressing Cardiac Na+-Ca2+ ExchangerThe Journal of general physiology, 1997
- Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart FailureScience, 1997