Haplotype analyses with the human leucocyte antigen and tumour necrosis factor‐alpha genes in narcolepsy families
Open Access
- 1 February 2001
- journal article
- Published by Wiley in Psychiatry and Clinical Neurosciences
- Vol. 55 (1) , 37-39
- https://doi.org/10.1046/j.1440-1819.2001.00782.x
Abstract
Our previous study suggested that the tumour necrosis factor‐alpha gene with thymine residue at position –857 in its promoter region [TNF‐α(–857T)] could be associated with human narcolepsy independently of a strong association of the human leucocyte antigen (HLA)‐DRB1*1501 with the disorder. To understand the relationship of DRB1*1501 with TNF‐α(–857T) in narcoleptic patients, we investigated 28 members of four Japanese narcolepsy families and determined the haplotypes with the HLA‐B, TNF‐α(–857C/T) and HLA‐DRB1 in the members. The resultant haplotypes indicated that not only the DRB1*1501‐TNF‐α(–857C) haplotype but also the DRB1*1501‐TNF‐α(–857T) haplotype, which is rare in healthy individuals and may have a strong predisposition to the disorder, were present in the affected members. From the chromosomal recombination observed in a few members, it is possible that chromosomal recombination could play a role in the generation of the rare DRB1*1501‐TNF‐α(–857T) haplotype.Keywords
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