Relationship of calcium exchange to changes in length, tension, and work in heart muscle

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Abstract
The exchange characteristics of Ca++ relative to alterations in length, tension, and work were studied in the isolated, arterially perfused dog papillary muscle and rabbit interventricular septum. The technique is capable of defining an average net change of [plus or minus]5% or greater in total tissue Ca++. Neither the ascending nor descending limb of the length-tension curve of isometrically contracting muscle was associated with net changes of Ca++. Similarly no changes in net Ca++ content were produced over large ranges of shortening and work in isotonically contracting muscles. The rate of exchange of Ca++ with the perfusing medium is also unaffected by alternations in length-tension characteristics and work done by the muscle.

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