The Patas Monkey as a Model for Dihydrostreptomycin Ototoxicity
- 1 January 1977
- journal article
- research article
- Published by Taylor & Francis in Acta Oto-Laryngologica
- Vol. 83 (1-6) , 123-129
- https://doi.org/10.3109/00016487709128821
Abstract
Although the cochlear toxicity of dihydro-streptomycin (DHSM) is well-recognized in man, it has always proved difficult to demonstrate in animals. Hearing thresholds in M. nemestrina monkeys remained essentially unchanged after DHSM 100 mg/kg im daily for 8 months, but E. patas monkeys were severely deafened by DHSM 20 mg/kg for 90 days, a regimen formerly used in treating human tuberculosis. The patas monkey may prove to be the animal model of choice for evaluating aminoglycoside ototoxicity.Keywords
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