The accumulated evidence on lung cancer and environmental tobacco smoke

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Abstract
Objective: To estimate the risk of lung cancer in lifelong non-smokers exposed to environmental tobacco smoke. Design: Analysis of 37 published epidemiological studies of the risk of lung cancer (4626 cases) in non-smokers who did and did not live with a smoker. The risk estimate was compared with that from linear extrapolation of the risk in smokers using seven studies of biochemical markers of tobacco smoke intake. Main outcome measure: Relative risk of lung cancer in lifelong non-smokers according to whether the spouse currently smoked or had never smoked. Results: The excess risk of lung cancer was 24% (95% confidence interval 13% to 36%) in non-smokers who lived with a smoker (PConclusion: The epidemiological and biochemical evidence on exposure to environmental tobacco smoke, with the supporting evidence of tobacco specific carcinogens in the blood and urine of non-smokers exposed to environmental tobacco smoke, provides compelling confirmation that breathing other people's tobacco smoke is a cause of lung cancer. A woman who has never smoked has an estimated 24% greater risk of lung cancer if she lives with a smoker Neither bias nor confounding accounted for the association There is a dose-response relation between a non-smoker's risk of lung cancer and the number of cigarettes and years of exposure to the smoker The increased risk was consistent with that expected from extrapolation of the risk in smokers using biochemical markers Tobacco specific carcinogens are found in the blood and urine of non-smokers exposed to environmental tobacco smoke All the available evidence confirms that exposure to environmental tobacco smoke causes lung cancer