BIOCHEMISTRY OF METALOCENES - ORGAN DISTRIBUTION OF HYDROXYACETYL [RUTHENOCENE-RU-103 AND ITS GLUCURONIDE IN MICE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 21  (1) , 63-66
Abstract
Hydroxyacetyl [103Ru]ruthenocene and its o-glucuronide were prepared in vitro by incubation of acetyl [103Ru]ruthenocene [a radiopharmaceutical with an affinity for the adrenal glands] with rat-liver homogenate, NADPH and UDP-glucuronate. The factors affecting hydroxylation and glucuronidation in vitro were optimized for acetylruthenocene. Hydroxyacetyl [103Ru]ruthenocene glucuronide showed no affinity for the adrenal glands, but after i.v. administration of hydroxyacetyl [103Ru]ruthenocene there was a distinct accumulation of 103Ru in adrenals, similar to that found after administration of acetyl [103Ru]ruthenocene.