Toxoplasma in Frogs

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Abstract
It has been a problem for many years as to whether Toxoplasma ever occurs naturally in cold-blooded animals, or whether they are even susceptible to infection with it. Splendore (1913) claimed to have successfully infected frogs, and Plimmer (1916) reported toxoplasmosis in a snake. The authors introduced heavy dosages of Toxoplasma (using the RH strain of human origin) into frogs, by the oral, intramuscular, intracerebral, and intraperitoneal routes. Results were checked byexamining tissue smears, and injecting emulsions of various organs (liver, spleen, lung, brain) into white mice, upon death or after sacrifice of the frogs. In no case could viable parasites be demonstrated in the frogs more that 3 days after injn., and then only in the brain.

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