Restricting Expression Prolongs Expression of Foreign Genes Introduced into Animals by Retroviruses
Open Access
- 1 November 2000
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 74 (21) , 10202-10206
- https://doi.org/10.1128/jvi.74.21.10202-10206.2000
Abstract
If foreign genes are ubiquitously expressed in mice using a viral vector, expression is abrogated by CD8+cells in 2 to 4 weeks. However, if the expression of the genes is confined to skeletal muscle cells, the CD8+T-cell response is much weaker and expression is maintained for more than 6 weeks. These data show that restricting the expression of foreign genes to skeletal muscle cells and presumably to other cells that are inefficient at antigen presentation can prolong the expression of a foreign gene product.Keywords
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