Variation in smoking-related lung cancer risk factors by cell type among men in Argentina: a case-control study

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Abstract
A high mortality rate for lung cancer (62.7 per 100,000) is found in Rosario, Argentina. To investigate the reasons for this high rate, a case-control study was carried out among 215 male cases with histologically confirmed lung cancer and 433 hospitalized controls for conditions unrelated to tobacco consumption. Odds ratios (OR) of squamous cell (SQ), adenocarcinoma (AD), and small cell (SM) carcinoma of the lung associated with different characteristics of the smoking habit were quantified. Ninety-eight percent of the cases had smoked regularly. Smokers were significantly younger at diagnosis than ex-smokers (Pcf the lowest consumption categories were 15.3 for SQ, 11.6 for AD, and 11.6 for all lung cancer (PP<0.001). To halt further increases in lung cancer, preventive measures in Argentina should be directed primarily towards smoking control.