LOCALIZATION OF PEROXIDASE ACTIVITY IN THE HUMAN NASAL GLAND. COMPARISON OF PATIENTS WITH A HOUSE DUST NASAL ALLERGY TO PERSONS WITH NORMAL GLANDS

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Abstract
Endogenous peroxidase activity was localized in seromucous-secretion cells of human nasal gland with the diaminobenzidine method for light microscopic and EM histochemistry. Localization of the activity occurred in the cisternae of rough surfaced endoplasmic reticulum, including the nuclear envelope, some vesicles and saccules of the Golgi complex, and secreting granules. In the case of patients with a house dust nasal allergy, peroxidase activity in the nasal glands diminished or disappeared. However, activity resumed after administration of steroid hormone (dexamethasone 5 mg/day for 7 days). If nasal glands rely on the same nervous system as do salivary glands, then the diminishing of peroxidase activity may be due to the diminishing of sympathetic stimulation. The relationship between nasal allergy and the sympathetic nerve was discussed.