Plasma Enzyme Actvity in Myocardial Infarction in Dog and Man.

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Abstract
Hemodynamic and biochemical studies were carried out in dogs following embolization of the coronary arteries with plastic spheres. There was a decrease in coronary flow, myocardial O2 usage, coronary vascular resistance, as well as negative myocardial pyruvate balance. At 24 hours the coronary flow and myocardial O2 usage had returned to normal. Increased plasma levels of transaminase as well as plasma fructose aldolase, hexose phosphate isomerase, and malic acid dehydrogenase activity occurred in dogs after experimental myocardial infarction and in humans suffering from coronary occlusion. Plasma levels of all enzymes were highest 24 hours following infarction and had fallen rapidly at 48 hours. A rapid and simple method is described for the determination of malic acid dehydrogenase activity in plasma.

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