SYNTHESIS OF 5-FLUORO-PRGSTAGLANDINS
- 5 December 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 8 (12) , 1499-1502
- https://doi.org/10.1246/cl.1979.1499
Abstract
(5E)- And (5Z)-5-fluoro-prostaglandin(PG)F2α methyl esters 1 and 2 were synthesized via decarboxylative elimination reaction from key intermediate α-fluoro-β-hydroxy ester 7. 5-Fluoro-6-keto-PGE1 methyl ester 3 was also synthesized from the key intermediate 7. These 5-fluoro-PGs 1, 2 and 3 showed interesting biological properties.Keywords
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