Granuloma coccidioides is a rare, usually fatal, infectious disease, caused by the organismCoccidioides immitis, the first case of which was reported by Wernicke1in Buenos Aires in 1892. In 1896, Rixford and Gilchrist2first described the morphologic characteristics of the organism, and recorded their observations of its clinical and microscopic pathology. In 1900, Ophuls3more accurately described the life cycle of the organism and noted that it multiplied in the host by endosporulation, a fact which definitely distinguishes this disease from blastomycosis, with which it was for a time confused. We have been able to find records of eighty-eight cases. It has been impossible to obtain accurate information on several points of interest, as many of the records are incomplete. Of the eighty-eight cases, some knowledge of the progress and outcome is known in seventy-three. Forty-nine of these patients, or 67 per cent, are known to