GROWTH-INHIBITING EFFECT OF CORTISONE ACETATE ON THE CHICK EMBRYO

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Abstract
In the course of a study of the effects of various agents on the development of the chick embryo (Karnofsky, Patterson and Ridgway, 1949, 1950, Karnofsky, Ridgway and Patterson, 1950), it was found that 11-dehydro-17-hydroxy-corticosterone acetate (cortisone acetate) caused a striking inhibition of embryonic growth and development (Karnofsky, Stock and Rhoads, 1950). This observation was anticipated by Landauer (1947), who found that an extract of the adrenal cortex, injected into the yolk sac of the 0, 1 or 5 day chick embryo markedly inhibited its subsequent growth. This report presents further studies on the growth-inhibiting effects of cortisone, when injected into the yolk sac or onto the chorioallantoic membrane of the chick embryo at various stages of development. Fertile white Leghorn eggs were obtained from a commercial source. They were incubated at 38° C. and 75 per cent relative humidity. The eggs were kept in one position, and moved once daily