DEPRESSION OF HYPOPHYSEAL ACTIVITY BY THE IMPLANTATION OF TABLETS OF OESTRONE AND OESTRADIOL

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Abstract
Introduction Numerous workers have reported that continued administration of oestrogenic preparations by daily subcutaneous injections will damage the reproductive organs of male rats. At first the damage was attributed to hormone antagonism [Steinach and Kun, 1926; Laqueur and de Jongh, 1928; Borchardt, Dingemanse, de Jongh, and Laqueur, 1929], but later when it had been shown that similar results could be obtained in female rats and mice1 it became likely that the gonadotrophic activity of the pituitary gland was affected. Moore and Price [1930, 1932], who reviewed the older papers, showed that the harmful effect of oestrogenic extracts in the male rat could be prevented by simultaneous injection of gonadotrophic substances which replaced the secretion of the animal's own pituitary. These writers found severe changes in the normal male rat after 20 days injection with 15–20 rat units of oestrogen daily—a comparatively low dose. Spencer, Gustavson, and D'Amour [1931] first showed

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