Sensing DNA Hybridization via Ionic Conductance through a Nanoporous Electrode
- 28 April 2005
- journal article
- Published by American Chemical Society (ACS) in Langmuir
- Vol. 21 (11) , 4776-4778
- https://doi.org/10.1021/la0471644
Abstract
We show that nanoporous alumina modified with covalently linked DNA can be used to detect target DNA by monitoring the increase in impedance at the electrode upon DNA hybridization, which resulted from blocking the pores to ionic flow. Using cyclic voltammetry, direct current conductance, and impedance spectroscopy we confirm the importance of pore size: the effect is observed with 20-nm-diameter pores and is absent for 200-nm pores.Keywords
This publication has 11 references indexed in Scilit:
- “Direct” Detection and Separation of DNA Using Nanoporous Alumina FiltersLangmuir, 2004
- Conical-Nanotube Ion-Current Rectifiers: The Role of Surface ChargeJournal of the American Chemical Society, 2004
- DNA-Functionalized Nanotube Membranes with Single-Base Mismatch SelectivityScience, 2004
- DNA-Mediated Fluctuations in Ionic Current through Silicon Oxide Nanopore ChannelsNano Letters, 2004
- Toward the Development of Ionically Controlled Nanoscopic Molecular GatesJournal of the American Chemical Society, 2004
- Nanotube Membrane Based BiosensorsElectroanalysis, 2004
- Probing Biomolecular Interactions at Conductive and Semiconductive Surfaces by Impedance Spectroscopy: Routes to Impedimetric Immunosensors, DNA‐Sensors, and Enzyme BiosensorsElectroanalysis, 2003
- Surface Effects on Cation Transport across Porous Alumina MembranesLangmuir, 1999
- Nanotubule-Based Molecular-Filtration MembranesScience, 1997
- Metal Nanotubule Membranes with Electrochemically Switchable Ion-Transport SelectivityScience, 1995