Horse-Chestnut Seed Extract for Chronic Venous Insufficiency

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Abstract
WITH A prevalence of 10% to 15% in men and 20% to 25% in women, chronic venous insufficiency (CVI) is among the most common conditions afflicting humans.1,2 It is more than a mere "cosmetic problem" because patients often require hospital admission and surgical treatment. At least two thirds of leg ulcers have evidence of venous disease in the affected limb.2 The burden of suffering is high, and the economic costs for society are considerable. Although the therapy of choice is mechanical compression,3 compliance is often poor, which renders oral drug treatment an attractive option.