Ipaf is upregulated by tumor necrosis factor‐α in human leukemia cells
- 18 May 2004
- journal article
- Published by Wiley in FEBS Letters
- Vol. 568 (1-3) , 79-82
- https://doi.org/10.1016/j.febslet.2004.04.095
Abstract
Ipaf has been associated with apoptosis, cytokine processing, and nuclear factor-κB activation. Here, we describe that Ipaf is highly expressed in myelomonocytic cells and that the mRNA levels of Ipaf progressively increase during differentiation of CD34 + progenitors to granulocytes and monocytes. Additionally, treatment with tumor necrosis factor-α and exposure to UV radiation induced the transcriptional activation of Ipaf in human leukemia HL-60 cells. Thus, Ipaf may contribute to modulate the response of myeloid cells to genotoxic and pro-inflammatory stimuli.Keywords
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