Histocompatibility-Linked Genetic Control of the Immune Response to Hapten Guinea Pig Albumin Conjugates in Inbred Guinea Pigs
Open Access
- 1 September 1972
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 109 (3) , 457-463
- https://doi.org/10.4049/jimmunol.109.3.457
Abstract
The immune response of inbred guinea pigs to low doses of hapten-guinea pig albumin conjugates is controlled by a specific immune response gene closely linked to the gene complex controlling strain 13 histocompatibility antigens. Thus, strain 13 guinea pigs make significant anti-dinitrophenyl (anti-DNP) antibody responses to 1 μg of DNP-guinea pig albumin (GPA) while strain 2 guinea pigs make little or no response and are not prepared for secondary anti-DNP responses. Progeny of (2 × 13) F1 × 2 matings which possess strain 13 histocompatibility antigens are good responders to a low dose of DNP-GPA while offspring lacking strain 13 antigens are poor responders. The differential response of strain 2 and 13 animals to DNP-GPA is also observed with p-iodophenylsulfonyl-GPA and a 3-(2,4-dinitrophenylamino)-propylamide derivative of GPA. These observations indicate that this immune response gene is involved in carrier recognition and suggest that it operates in thymus-derived lymphocytes.Keywords
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