Quantitation of Ineffective Erythropoiesis from the Incorporation of [15N]Delta‐aminolaevulinic Acid and [15N]Glycine into Early Labelled Bilirubin: I. NORMAL SUBJECTS

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Abstract
SUMMARY The incorporation of [15N]glycine into early labelled bilirubin and haemoglobin haem was measured in four haematologically normal subjects, using the clearance of [14C] bilirubin to measure total bilirubin production rate. Hepatic haem turnover was calculated from the incorporation of [15N]δ‐aminolaevulinic acid into early labelled bilirubin. From the experimental data and previously published data in normal subjects a method is derived for the quantitation of ineffective erythropoiesis which can be applied to similar studies in patients with haemato‐logical disorders.