Iodomycin and iodipine, a structural analogue of azidopine, bind to a common domain in hamster P‐glycoprotein

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Abstract
Both the overexpression of P‐glycoprotein and the broad range of substrates of this ATP‐binding cassette (ABC) transporter induce the phenomenon of multidrug resistance, one major cause of the failure of cancer chemotherapy in humans. This study reports that [125I]iodipine, a structural analogue of the 1,4‐dihydropyridine azidopine, shares a common binding site with iodomycin, a Bolton–Hunter derivative of the anthracycline daunomycin. This binding site is different from that described for iodoarylazidoprazosin, which is presumed to share a common binding site with azidopine. Edman sequencing revealed that [125I]iodipine had photolabelled the same peptide as iodomycin and spans the primary sequence of hamster isoform pgp1 from amino acid 230 to amino acid 312.