THE EFFECT OF NERVE STIMULATION ON THE AXONAL TRANSPORT OF NORADRENALINE AND DOPAMINE‐β‐HYDROXYLASE
Open Access
- 1 December 1974
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 52 (4) , 527-531
- https://doi.org/10.1111/j.1476-5381.1974.tb09720.x
Abstract
1 A method for stimulating the lumbar sympathetic outflow from the spinal cord of the rat is described which does not require artificial respiration of the animal. 2 In some, but not all experiments continuous stimulation at 2 Hz or intermittently at 10 Hz accelerated the rate at which noradrenaline and dopamine-β-hydroxylase accumulated central to a ligature on the sciatic nerve by approximately 40%. 3 It is concluded that, although nervous activity is not necessary for axonal transport of transmitter granules in sympathetic neurones, intense nervous activity may accelerate the rate of granule transport.Keywords
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