Delayed Consequences of Endothelial Removal from Rabbit Aortae
- 1 January 1978
- book chapter
- Published by Springer Nature
- Vol. 102, 165-173
- https://doi.org/10.1007/978-1-4757-1217-9_10
Abstract
One year after de-endothelialization of rabbit aorta by a balloon catheter, the damaged areas show arteriosclerotic thickening. In the study described here, aortae from six rabbits were examined 2 years after the single injury. Three had advanced atherosclerotic lesions. All the animals had been fed standard rabbit chow, and the five tested did not have hypercholesterolemia when they were sacrificed. Apparently vascular injury alone is sufficient basis for development of atherosclerotic disease in the rabbit.Keywords
This publication has 2 references indexed in Scilit:
- Effect of regenerated endothelium on lipid accumulation in the arterial wall.Proceedings of the National Academy of Sciences, 1977
- Intimal injury and regrowth in the rabbit aorta; medial smooth muscle cells as a source of neointima.Circulation Research, 1975