Hemagglutination with Aldehyde-Fixed Erythrocytes for Assay of Antigens and Antibodies.

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Abstract
Methods were described for the preservation of sheep erythrocytes by brief treatment with glutaraldehyde. These cells could be conjugated to proteins in the presence or absence of coupling reagents and were specifically agglutinated by specific anti-protein sera. These antigen-conjugated cells were stable for at least 6 mos. Utilizing these cells, the inhibition of hemagglutination was found to be a sensitive technique for detection of small amounts of antigen.