Determination of Tertiary Amines as Pentafluorobenzyl Carbamates by Electron Capture Gas Chromatography
- 1 April 1974
- journal article
- separations
- Published by Taylor & Francis in Analytical Letters
- Vol. 7 (4) , 223-231
- https://doi.org/10.1080/00032717408058183
Abstract
A new, electrophore containing reagent, pentafluorobenzyl chloroformate, is introduced for the direct determination of tertiary amines with electron capture gas chromatography. Use of a base catalyst, Na2CO3, gives complete carbamate formation in less than 30 minutes. The derivatives are stable and have excellent sensitivity in an electron capture detector as the minimum detectable quantity is in the order of 1 × 10−16 moles/sec or corresponding to about 3 pg in an injected sample. The reagent has been tested for quantitative determinations in the range 12–120 μg/ml with the recovery 100 ± 2.6% at the 60 μg/ml level.Keywords
This publication has 7 references indexed in Scilit:
- Electron Capture Gas Chromatography of Tertiary Amines After a Demethylation Reaction to Secondary AminesAnalytical Letters, 1973
- Gas chromatographic determination of pentazocine in human plasma by means of electron-capture detectionJournal of Chromatography A, 1973
- Determination of N,N-dimethyldibenzo [b,f]thiepin-10-methylamine by gas—liquid chromatographyJournal of Chromatography A, 1973
- Electron-Capture Sensitivity Comparison of Various Derivatives of Primary and Secondary AminesJournal of Pharmaceutical Sciences, 1972
- Effect of detector temperature on the sensitivity of some electron absorbing derivativesChromatographia, 1969
- Microdetermination of derivatives of phenols and mercaptans by means of electron capture gas chromatographyAnalytical Chemistry, 1968
- Benzoxazolone Formation in the Attempt to Prepare Certain Mixed Diacyl Derivatives of o-AminophenolJournal of the American Chemical Society, 1934