Pharmacokinetics of cinoxacin in patients with renal failure
- 1 September 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 4 (5) , 451-454
- https://doi.org/10.1093/jac/4.5.451
Abstract
The pharmacokinetics of cinoxacin, a new synthetic organic compound useful in the treatment of urinary tract infection, were evaluated in 20 patients with chronic renal failure and in 4 normal subjects. The half-life of cinoxacin closely correlated with creatinine clearance as did the amount of cinoxacin excreted in the urine. Urinary concentrations were adequate to inhibit susceptible microorganisms even in patients with severe renal failure. Guidelines for the use of cinoxacin in patients with renal failure were formulated.Keywords
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