Gq and G11 are concurrently activated by bombesin and vasopressin in Swiss 3T3 cells
Open Access
- 1 August 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 349 (2) , 201-204
- https://doi.org/10.1016/0014-5793(94)00667-9
Abstract
The α‐subunits of the widely expressed G‐proteins Gq and G11 indistinguishably activate β‐isoforms of phospholipase C. In this report we have tested whether differences exist in the activation of both G‐proteins via phospholipase C‐linked receptors. We found that bombesin and vasopressin, with very similar potencies and time dependencies, induce the activation of both Gq and G11 in Swiss 3T3 cells, suggesting that these G‐proteins, at least in part, serve interchangeable functions.Keywords
This publication has 18 references indexed in Scilit:
- [22] Identification of receptor-activated G proteins: Selective immunoprecipitation of photolabeled G-protein α subunitsPublished by Elsevier ,1994
- Regulation of phospholipase C by G proteinsTrends in Biochemical Sciences, 1992
- Widespread distribution of Gqα/Gllα detected immunologically by an antipeptide antiserum directed against the predicted C‐terminal decapeptideFEBS Letters, 1991
- Two α subunits of the Gq class of G proteins stimulate phosphoinositide phospholipase C‐β1 activityFEBS Letters, 1991
- The PtdIns-PLC superfamily and signal transductionBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1991
- Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells.Proceedings of the National Academy of Sciences, 1991
- [25] Identification of receptor-activated G proteins with photoreactive GTP analog, [α-32P]GTP azidoanilidePublished by Elsevier ,1991
- G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.Proceedings of the National Academy of Sciences, 1990
- Ca2+-mobilizing actions of platelet-derived growth factor differ from those of bombesin and vasopressin in Swiss 3T3 mouse cells.Proceedings of the National Academy of Sciences, 1987
- Early Signals in the Mitogenic ResponseScience, 1986