Immunization of Macaca fascicularis with inactivated SIV preparations: Challenge with human‐ or monkey‐derived SIV and the effects of a longer immunization schedule

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Abstract
In cynomolgus monkeys, we compared two human‐derived SIVmac251 whole virus vaccines, a long vs short immunization schedule, and two different challenge viruses. Both vaccines induced protection after challenge with human‐derived SIVmac251/32H. There was no difference between the two schedules of immunization. Seven monkeys, five of which were protected following the first challenge, were reboosted and rechallenged with monkey‐derived SIVmac251, but no protection was observed. The titers of anti‐human cell or ‐SIV neutralizing antibodies were not related to protection.