Expression of α and β thyroid receptors during oligodendrocyte differentiation

Publisher Website
Google Scholar
Abstract
To determine which thyroid receptor (TR) isoforms are expressed during oligodendrocyte differentiation, we studied the expression of the mRNAs encoding two α (α1 and α2) and one β (β1) TR isoforms in a bipotential oligodendrocyte-type 2-astrocyte (O-2A) progenitor cell line (CG-4) as well as in rat O-2A progenitor cells and oligo-dendrocytes. O-2A progenitor cells expressed only TRα-mRNAs, whereas oligodendrocytes and type 2-astrocytes also expressed TRβ1-mRNAs. The differential expression of α1 and β1 TRs suggests specific functions for both types of TRs during oligodendrocyte differentiation. We present evidence for a possible role of TRαl in the effect of thyroid hormones on the proliferation of CG-4 cells maintained as progenitor cells.

This publication has 0 references indexed in Scilit: