Stimulation of Calcitonin Secretion Rate by 25,26-Dihydroxycholecalciferol in Vitamin D-Depleted Pigs

1 January 1981

journal article
research article
Published by Georg Thieme Verlag KG in Hormone and Metabolic Research

Vol. 13 (01) , 53-55
https://doi.org/10.1055/s-2007-1019166

Abstract

The thyroid gland was surgically isolated in situ in young, vitamin D-depleted pigs and perfused with autologous blood under controlled conditions. The thyroid venous blood was quantitatively collected and the calcitonin (CT) concentration measured by radioimmunoassay. The addition of 25R,26-dihydroxycholecalciferol (25R,26-(OH)₂D₃), 25S,26-(OH)₂D₃ or 25RS,26-(OH)₂D₃) to the perfusing blood to raise the concentration by 0.65 to 10.0 ng/ml caused a significant increase in the secretion rate of CT.

Keywords

This publication has 3 references indexed in Scilit:

The 26-hydroxylation of 25-hydroxyvitamin D3 in vitro by chick renal homogenates
Biochemical and Biophysical Research Communications, 1978
Assay of plasma 25-hydroxy vitamin D
Clinica Chimica Acta; International Journal of Clinical Chemistry, 1976
A Study of Thyrocalcitonin Secretion by Direct Measurement ofin VivoSecretion Rates in Pigs¹
Endocrinology, 1968