TC-99M DEXTRAN - A NEW BLOOD-POOL-LABELING AGENT FOR RADIONUCLIDE ANGIOCARDIOGRAPHY

  • 1 January 1982
    • journal article
    • research article
    • Vol. 23  (4) , 348-353
Abstract
The possibility of imaging the cardiac blood pool with dextran (Dx) labeled with 99mTc after Sn2+ reduction was explored. Stannous dextran (SnDx) kits were prepared in advance and labeling was performed by adding 99mTc. The labeling efficency was > 95%. 99mTc dextran (TcDx) was highly stable both in vivo and in vitro. In 7 dogs, the quality of blood-pool images obtained with 99mTcDx of different MW (4 .times. 104 = Dx-40; 5 .times. 105 = Dx-500; 2 .times. 106 = Dx-2000) and with 99mTc red blood cells (TcRBC) labeled in vitro, and determined the organ distribution of this new agent by whole-body scanning and blood sampling. 99mTcDx provided high-quality cardiac blood-pool images up to 60 min after injection. The heart-to-lung ratios averaged 3.7 for 99mTcDx-40, 3.9 for 99mTcDx-500 and 5.4 for TcRBC at 60 min. While 99mTcDx-40 showed a relatively rapid initial urinary excretion and 99mTcDx-2000 was degraded rapidly, TcDx-500 demonstrated the best kinetics for blood-pool imaging. 99mTcDx is a new radiopharmaceutical with high labeling efficiency and stability. It overcomes a number of the limitations of currently used blood-labeling agents and may become useful for blood-pool imaging in man.

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