The excretion of a metabolic product of salicylic acid

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Abstract
The substance excreted in urine after salicylate adm., and causing the urine to turn dark on addition of NaOH in air, has been identified as gentisic acid; it appears in rat urine also after adm. of aspirin and methylsalicylate but not after salol or sulpho-salicylate. In rats poisoned with P or CCl4 it was not excreted after salicylate treatment but the effect of the poisoning was transient. Phlorhidzin did not prevent but rather increased its formation: nor was this prevented by large doses of ascorbic acid which, however, completely abolished the excretion of homogentisic acid in alkaptonuria.

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