Microsatellite Instability
- 17 July 2003
- journal article
- editorial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 349 (3) , 209-210
- https://doi.org/10.1056/nejmp038099
Abstract
Microsatellites are stretches of DNA in which a short motif (usually one to five nucleotides long) is repeated several times. A typical mononucleotide-repeat microsatellite might be, for instance, a stretch of 13 adenines, abbreviated (A)13. The most common microsatellite in humans is a dinucleotide repeat of cytosine and adenine, (CA)n, which occurs in tens of thousands of locations in our germ line. Trinucleotide repeats are prone to expansion in meiosis, and when abnormally expanded they lead to a variety of neurologic disorders (such as Huntington's disease, the best known of these) and fragile chromosomal sites (such . . .Keywords
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