A Method for Differentiation and Analysis of Quinine and Quinidine by Gas Chromatography/Mass Spectrometry
- 31 October 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 5 (6) , 275-278
- https://doi.org/10.1093/jat/5.6.275
Abstract
A method is presented for the positive identification of quinine and quinidine. The method requires extraction of the compounds from an alkaline solution into an organic solvent and concentration of the sample by evaporation of the solvent. The sample is chromatographed without derivatization and may be detected by the flame ionization detector (FID) or mass spectrometry (MS). Limits of sensitivity are less than 5 ng per assay for the underivatized compounds. Analysis of urine extracts is discussed.This publication has 2 references indexed in Scilit:
- High-performance liquid chromatographic separation and isolation of quinidine and quinine metabolites in rat urineJournal of Chromatography B: Biomedical Sciences and Applications, 1980
- Serum quinidine concentrations: comparison of fluorescence, gas-chromatographic, and gas-chromatographic/mass-spectrometric methods.Clinical Chemistry, 1976