Unpredictable error in calculated bicarbonate homeostasis during pediatric intensive care: the delusion of fixed pK'.
Open Access
- 1 January 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 29 (1) , 69-73
- https://doi.org/10.1093/clinchem/29.1.69
Abstract
Bicarbonate balance is usually calculated from indirect total CO2 values determined by blood-gas analysis. Total CO2 is computed from the Henderson-Hasselbalch equation, under the assumption that the pK' is constant or at most varies insignificantly. In pediatric patients in intensive care, we have found instances of large errors in this assumption. We join Natelson and Nobel in asserting that total CO2 should be measured. Little reliance should be placed on bicarbonate estimation.This publication has 5 references indexed in Scilit:
- Evaluation of ampouled tonometered buffer solutions as a quality-control system for pH, pCO2, and pO2 measurement.Clinical Chemistry, 1977
- Use of equilibrated blood for internal blood-gas quality control.Clinical Chemistry, 1977
- An evaluation of the Beckman chloride/carbon dioxide analyzer.Clinical Chemistry, 1976
- A Critique of the Parameters Used in the Evaluation of Acid-Base DisordersNew England Journal of Medicine, 1963
- ROUTINE USE OF ULTRAMICRO METHODS IN THE CLINICAL LABORATORY - ESTIMATION OF SODIUM, POTASSIUM, CHLORIDE, PROTEIN, HEMATOCRIT VALUE, SUGAR, UREA AND NONPROTEIN NITROGEN IN FINGERTIP BLOOD - CONSTRUCTION OF ULTRAMICRO PIPETS - A PRACTICAL MICROGASOMETER FOR ESTIMATION OF CARBON DIOXIDE1951