Arachidonic acid and arachidonoyldiglycerols increase in rat cerebrum during bicuculline-induced status epilepticus
- 1 July 1982
- journal article
- research article
- Published by Springer Nature in Neurochemical Research
- Vol. 7 (7) , 839-843
- https://doi.org/10.1007/bf00965677
Abstract
Bicuculline-induced status epilepticus was found to be associated with increased amounts offree fatty acids and diacylglycerols in the rat cerebrum. The predominant fatty acid in both lipid pools was arachidonic acid. The accumulation of arachidonoyl-diglycerols decreased at the time of and during behavioral seizures induced by bicuculline, while the amount of free arachidonic acid appeared to increase. We propose a metabolic relationship between these lipids to explain the described changes. The similarities between the composition of the lipid pools and the fatty acid composition of phosphatidylinositol support the hypothesis that these changes may be a result of a convulsion-activated degradation of this phospholipid from excitable membranes.This publication has 15 references indexed in Scilit:
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