Postantibiotic Effect of Trovafloxacin against Gram-Positive and -Negative Organisms
- 1 June 1998
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 42 (6) , 1503-1505
- https://doi.org/10.1128/aac.42.6.1503
Abstract
Trovafloxacin pneumococcal and staphylococcal postantibiotic effects (PAEs) were 0.7 to 1.8 and 0.7 to 2.4 h, respectively. For Escherichia coli and Pseudomonas aeruginosa , PAEs were 2.4 to 4.4 h. Pneumococcal and staphylococcal postantibiotic sub-MIC effects (PA-SMEs) (0.4 times the MIC) were 2.3 to 3.7 and 2.4 to >9.2 h, respectively, and E. coli PA-SMEs (0.3 times the MIC) were 6.8 to >12.0 h. For one P. aeruginosa strain, the PA-SME (0.4 times the MIC) was >10 h; in the other, rapid bactericidal activity precluded measurement.Keywords
This publication has 14 references indexed in Scilit:
- Activity of CP 99,219 (trovafloxacin) compared with ciprofloxacin, sparfloxacin, clinafloxacin, lomefloxacin and cefuroxime against ten penicillin-susceptible and pencillin-resistant pneumococci by time-kill methodologyJournal of Antimicrobial Chemotherapy, 1996
- Pharmacokinetics and safety of trovafloxacin (CP-99, 219), a new quinolone antibiotic, following adminstration of single oral doses to healthy male volunteersJournal of Antimicrobial Chemotherapy, 1995
- Activity of CP 99, 219 compared with DU-6859a, ciprofloxacin, ofloxacin, levofloxacin, lomefloxacin, tosufloxacin, sparfloxacin and grepaloxacin against penicillin-susceptible and -resistant pneumococciJournal of Antimicrobial Chemotherapy, 1995
- In vitro activity of the new fluoroquinolone CP-99,219Antimicrobial Agents and Chemotherapy, 1994
- Activity of CP 99,219 compared with those of ciprofloxacin, grepafloxacin, metronidazole, cefoxitin, piperacillin, and piperacillin-tazobactam against 489 anaerobesAntimicrobial Agents and Chemotherapy, 1994
- The post-antibiotic effectJournal of Antimicrobial Chemotherapy, 1993
- Studies on the postantibiotic effect and the postantibiotic sub-MIC effect of meropenemJournal of Antimicrobial Chemotherapy, 1993
- In vitro activity of CP-99,219, a new fluoroquinolone, against clinical isolates of gram-positive bacteriaAntimicrobial Agents and Chemotherapy, 1993
- The post-antibiotic sub-MIC effect in vitro and in vivoJournal of Antimicrobial Chemotherapy, 1993
- Postantibiotic sub-MIC effects of vancomycin, roxithromycin, sparfloxacin, and amikacinAntimicrobial Agents and Chemotherapy, 1992