Induction of chromosome aberrations, sister chromatid exchanges, and specific locus mutations in Chinese hamster ovary cells by 5-bromodeoxyuridine

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Abstract
The induction of cytotoxicity, growth inhibition, specific locus mutations, and cytological alterations such as micronuclei, chromosome/chromatid aberrations, and sister chromatid exchanges by 5-bromodeoxyuridine (BudR) in Chinese hamster ovary cells was determined. BudR shows concentration-dependent increases in cytological alterations over the range of 5–500 µM, but it is mutagenic only at concentrations greater than 50 µM.