Über die Rolle des Glutathions im lebenden Gewebe.

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Abstract
Cysteine formation from glutathione increases with temp. and time. Glutathione does not form a reversible oxidation-reduction system in the living cell, but is the inactive precursor of the SH-substance. It gives rise to the active SH-substance when a heavy metal and cysteine are present and have formed a complex salt which specifically catalyzes the oxidation of the glutathione. The cysteine required is split off from the inert glutathione when the respiratory function of the tissue is impaired. In normal tissues this process is slight and transient; in cancer tissue it is active and persistent. As a result the activation of glutathione is regulated and hence of the methylglyoxalase. As long as the latter is activated methylglyoxal undergoes dismutation to lactic acid and the resynthesis to carbohydrate is suppressed. In this way an indirect inhibition of the Pasteur-Meyerhof reaction occurs.

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