Runx2, A multifunctional transcription factor in skeletal development
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- 1 January 2002
- journal article
- review article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 87 (1) , 1-8
- https://doi.org/10.1002/jcb.10276
Abstract
The identification of Runx2 (runt‐related protein 2) function has greatly advanced the understanding of skeletal development over the last 5 years. Runx2 is regulated transcriptionally and post‐translationally through the activity of many identified factors, although, the physiological significance of each remains to be demonstrated. The interaction of Runx2 with other transcription factors and cofactors has been shown to be important in Runx2‐dependent gene regulation. Runx2 plays important roles in multiple steps of skeletal development. Runx2 determines the lineage of osteoblasts from multipotent mesenchymal cells, enhances osteoblast differentiation at an early stage, and inhibits osteoblast differentiation at a late stage. Runx2 plays crucial roles in chondrocyte maturation and in the specification of cartilage phenotypes. Furthermore, Runx2 is involved in vascular invasion into cartilage and osteoclastogenesis. Therefore, the determination of Runx2 function and the investigation of the cascades of Runx2‐dependent gene regulation are important in the elucidation of skeletal biology. J. Cell. Biochem. 87: 1–8, 2002.Keywords
This publication has 50 references indexed in Scilit:
- Impaired Vascular Invasion of Cbfa1-Deficient Cartilage Engrafted in the SpleenJournal of Bone and Mineral Research, 2002
- A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formationThe Journal of cell biology, 2001
- Skeletal Malformations Caused by Overexpression of Cbfa1 or Its Dominant Negative Form in ChondrocytesThe Journal of cell biology, 2001
- Cbfa1 Contributes to the Osteoblast-specific Expression of type I collagen GenesJournal of Biological Chemistry, 2001
- A Fundamental Transcription Factor for Bone and CartilageBiochemical and Biophysical Research Communications, 2000
- The Osteoblast-specific Transcription Factor Cbfa1 Contributes to the Expression of Osteoprotegerin, a Potent Inhibitor of Osteoclast Differentiation and FunctionJournal of Biological Chemistry, 2000
- Multilineage Differentiation of Cbfa1-Deficient Calvarial Cells in VitroBiochemical and Biophysical Research Communications, 2000
- Runt Domain Factor (Runx)-dependent Effects on CCAAT/ Enhancer-binding Protein δ Expression and Activity in OsteoblastsJournal of Biological Chemistry, 2000
- Inhibition of Osteoblast-specific Transcription Factor Cbfa1 by the cAMP Pathway in Osteoblastic CellsJournal of Biological Chemistry, 1999
- Potential Role of Cbfa1, an Essential Transcriptional Factor for Osteoblast Differentiation, in Osteoclastogenesis: Regulation of mRNA Expression ofOsteoclast Differentiation Factor(ODF)Biochemical and Biophysical Research Communications, 1998