Short Communication
- 1 June 1995
- journal article
- research article
- Published by Wolters Kluwer Health in Therapeutic Drug Monitoring
- Vol. 17 (3) , 302-304
- https://doi.org/10.1097/00007691-199506000-00014
Abstract
After informed consent was obtained and with the approval of the Local Ethical Committee, cyclosporine A (CsA) kinetics was studied in 63 psoriatic patients by giving them 2.5 mg/kg CsA orally. In order to calculate oral bioavailability, F, 22 patients were given the same dose i.v. Values of the calculated kinetic parameters were oral F = 22–63%; half-life, t1/2β, = 11.05–13.70 h; volume of distribution, Vd, = 4.00–5.02/L/kg; total body clearance, Cl, = 4.25–4.14 ml/min/kg. The area under the blood concentration time curve was more closely related to the dose (r = 0.66) than were trough levels (r = 0.52). No significant relationship was observed between the kinetic parameters studied and the age of the patient.Keywords
This publication has 0 references indexed in Scilit: