Strict peptide length is not required for the induction of cytotoxic T lymphocyte‐mediated antiviral protection by peptide vaccination
- 1 May 1993
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 23 (5) , 1189-1192
- https://doi.org/10.1002/eji.1830230534
Abstract
Sendai virus nuclear protein peptides of different lengths were titrated in peptide vaccination experiments. We observed that peptide length was not important in inducing cytotoxic T lymphocyte-mediated protective immunity in vivo against a challenge with a lethal dose of virus. These results suggest that long peptides are trimmed in vivo to peptides that fit into the groove of major histocompatibility complex class I molecules. In addition several adjuvants were screened for their effectiveness in peptide vaccination protocols. Incomplete Freund's adjuvant and Titermax™ turned out to be useful, whereas alum was much less effective.Keywords
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