GENETIC-POLYMORPHISM OF SERUM ALPHA-1-PROTEASE INHIBITOR (ALPHA-1-ANTITRYPSIN) - PI L, A DEFICIENT ALLELE OF PI-SYSTEM

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 92  (2) , 177-184
Abstract
The microheterogeneity of the l allele of the Pi [protease inhibitor] system of APi (alpha-1-antitrypsin) was studied in 43 individuals with the new PAGIF [polyacrylamide gel isoelectric focusing] technique. The unique aspect of the l allele product (unequal distribution of bands 4 and 6), previously demonstrated with acid-starch gel, was confirmed. Two subtypes of the Pi l allele, l1 and l2, were, clearly distinguished. Serum concentrations of APi associated with the expression of the l allele were significantly decreased (68% of normal values) and very similar to those associated with the expression of the S allele. The l allele can be considered as a deficient allele of the Pi system.