Gardimycin, a new antibiotic from Actinoplanes. II. Isolation and preliminary characterization.

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Abstract
A. garbadinensis produces a peptide antibiotic, named gardimycin, which is active in vitro and in vivo against gram-positive bacteria. Isolation and purification of the product were accomplished by extraction from the broth with butanol and dialysis of the crude extract, followed by counter-current distribution. Gardimycin is an open chain peptide with an approximate minimal formula .**GRAPHIC**. . The following amino acids were identified by column chromatography of an acid hydrolysate: serine, glutamic acid, alanine, leucine, isoleucine, glycine, valine and 2 S-containing amino acids whose structure is presently under study. Tryptophan was identified in an alkaline hydrolysate.

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