DEPOSITION OF SIZED GLASS FIBRES IN THE RESPIRATORY TRACT OF THE RAT
- 1 November 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Annals of Occupational Hygiene
- Vol. 23 (4) , 353-366
- https://doi.org/10.1093/annhyg/23.4.353
Abstract
A study has been made of the regional deposition of inhaled glass fibres of discrete size in the respiratory tract of the rat using a radioactive tracer technique. The samples used included four with nominal dia. 1.5 μm and lengths ranging from 5 to 60 μm and one with nominal dia. 3 μm and length 10 μm. Deposition of the longer 1.5 μm dia. fibres in the respiratory tract was quantitative as was that of the 3 μm dia. fibre. Alveolar deposition was much lower than for asbestiform minerals owing to the larger aerodynamic diameters of the samples of glass fibre. It appears that, in the rat, fibres are only respirable when their median aerodynamic diameter is less than 6 μm. Additional information on the lobar distribution of fibres immediately following administration is provided.Keywords
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