Cerebral Edema in Water Intoxication

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Abstract
PREVIOUS morphological studies of cerebral edema in water intoxication have been concerned exclusively when gray matter,1-5although it has been well established that the greatest chemical swelling occurs in white matter.6Most observers have found an increase in water content of the brain6-10and swelling of glial cells1,7in water intoxication, but Gerschenfeld et al have claimed that no chemical or morphological change occurs in the brain in the presence of severe water intoxication.7In view of this controversy, and because of the often-noted differences in the behavior of white and gray matter in other types of brain swelling,11-16we undertook this morphological study of white matter edema in water intoxication. It was hoped that such a work, in addition to complementing our chemical data on water intoxication,17might provide useful information regarding fluid pathways in the brain. Material and Methods Thirty

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