PRIMARY CEREBRAL MALIGNANT LYMPHOMA OF THE HISTIOCYTIC TYPE

Abstract
A 60 yr old housewife complained of anorexia, headaches and vomiting for several months. Later she developed disturbances in gait. At the terminal stage of her clinical course, 3 masses in the cerebrum and 1 in the cerebellum were detected by angiography and CT[computed tomography]-scan. At autopsy, 3 masses in the frontal lobes and 1 in each thalamus and still another in the cerebellum were found. They were accompanied with necrotic and hemorrhagic changes. Tumor cells were large, irregular or round in shape and showed metallophilia by the silver impregnations for reticulum cells and microglia. Some were multinucleated giant cells. Tumor cells showed occasional phagocytic activity. Perivascular infiltration of tumor cells was marked around the tumor masses.

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