STUDIES ON CONTROL OF ANTIBODY-SYNTHESIS .12. GENETIC INFLUENCES ON ANTIBODY AFFINITY
- 1 January 1978
- journal article
- research article
- Vol. 34 (4) , 669-678
Abstract
Genetic controls on the concentration and affinity of the anti-dinitrophenyl antibodies produced by different inbred strains of mice in response to immunization with dinitrophenylated bovine .gamma.-globulin in Freund''s complete adjuvant were demonstrated. Based upon data on F1 hybrids and backcrosses, there are genetic controls on antibody affinity which are not linked to the major histocompatibility complex. The genetic controls on affinity which were studied appear to be inherited independently of genetic controls on antibody concentration.This publication has 20 references indexed in Scilit:
- Studies on the Genetic Control of Antibody Affinity: The Independent Control of Antibody Levels and Affinity in Biozzi MiceThe Journal of Immunology, 1976
- Studies on the control of antibody synthesis. VII. Change in affinity of direct and indirect plaque-forming cells with time after immunization in the mouse: loss of high affinity plaques late after immunization.1975
- INHERITANCE OF ANTIBODY SPECIFICITYThe Journal of Experimental Medicine, 1974
- The Genetic Control of Antibody Binding Constants and Specificities in Inbred RatsThe Journal of Immunology, 1974
- Distribution of antibody affinities: Technique of measurementImmunochemistry, 1972
- Histocompatibility-Linked Immune Response GenesScience, 1972
- Effect of Tolerance and Immunity on Antibody AffinityImmunological Reviews, 1972
- Rate of Increase of Antiboby Affinity in Different Rat StrainsInternational Archives of Allergy and Immunology, 1971
- Purification of antibodies with immunoadsorbents prepared using bromoacetyl celluloseImmunochemistry, 1967
- Variations in Affinities of Antibodies during the Immune Response*Biochemistry, 1964