OESTROGEN AND PROGESTERONE RECEPTOR CONCENTRATIONS IN HUMAN ENDOMETRIUM DURING GESTATION

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Abstract
The concentrations of endometrial estrogen and progesterone [P] receptors, both in cytosol and in nuclei, were studied at 8-10 wk and at 38-40 wk of gestation. At these 2 periods, the concentration of estrogen receptors is comparable to the concentration observed during the late secretory phase of the menstrual cycle. At 8-10 wk of gestation, concentration of P receptors is also comparable with the concentration observed during the secretory phase of the menstrual cycle, but at term there is a significant increase (P < 0.05) and the concentration is then comparable with the concentration observed in the preovulatory period of the menstrual cycle. The receptor binding sites are always predominantly found in nuclei and the increase in P nuclear receptor at term suggests that, in man, the P withdrawal is not a necessary step in the mechanism of uterine activation during parturition as it is in other species.

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